The prescription anti-nausea medication Ondansetron (Zofran) is the first line drug for nausea in the emergency department (ED) for non-cancer patients. Now, an alternative option, inhaled isopropyl alcohol, has shown promise. Yes, this is your typical rubbing alcolhol that you may have in your bathroom cabinet.

A recent trial involved 120 ED adult patients with nausea and vomiting who did not need IV (intravenous) medications or fluids. They were randomized to receive inhaled isopropyl alcohol in the form of alcohol swabs plus 4 mg of oral ondansetron, inhaled isopropyl alcohol plus an oral placebo, or inhaled saline plus 4 mg oral ondansetron. Patients could sniff the alcohol or saline repeatedly.

Results showed a significant decrease in nausea in the alcolhol/ondansetron and alcohol/placebo groups than in the saline/ondansetron group. Patients in the alcohol groups also had better nausea control at the time of discharge.

For patients who do not require IV therapy, consider repeated inhalations of isopropyl alcohol swabs (which you can buy at your local pharmacy). We don’t know the mechanism of action, but it is simple and safe to try. Call your doctor or get to the ED if your symptoms worsen. And maybe don’t eat the old leftovers in the frig next time…

Reference: April MD et al. Aromatherapy vs oral ondansetron for antiemetic therapy among adult emergency department patients. A randomized control trial. Ann Emerg Med 2018 Aug; 72-:184.
Photo by Internet Archive Book Images

Photo by Internet Archive Book Images

There may be some new discoveries in Alzheimers disease.

This article explains some of the new insights into the causes of the most common type of dementia, Alzheimers disease.
Scientists have reviewed years of research and have noticed the virus herpes, appears to interact with human genes known to increase Alzheimers risk. This is not the sexually transmitted disease herpes but other types known as HHV-6 and HHV-7.
This combination of genetic and infectious influence can cause an overactive immune system.

The amyloid protein theory may still play a part in contributing to this disease but it has been losing ground in the thought that it was the only cause of Alzheimers.

Strong consideration of microbes actually being the initial seed that provokes a toxic turmoil is being looked at. This amyloid protein has the potential to build up to fight infection which then begins to impair function of neurons in the brain. The excess amyloid causes another protein called tau, to form tangles which can damage more brain cells and produce inflammation that stimulates the immune system. It is this inflammation, according to Harvard neuroscientist, Rudolph Tanzi, that does the most damage and causes a neurotoxic mess to the Alzheimer’s-afflicted brain. Scientific research has for the past few decades, clearly demonstrated that inflammation is a fundamental process that underlies the development of Alzheimer’s disease.

Tanzi explains that microbes may be the initial seed for the complex pathology of Alzheimer’s but that genetics and environmental factors also come into play.

In my opinion, we will find that the microbiome plays an important role in this discovery since its genetic makeup can regulate gene expression as well as modulate inflammation in the immune system.

https://www.npr.org/sections/health-shots/2018/09/09/645629133/infectious-theory-of-alzheimers-disease-draws-fresh-interest

There is something you should know about buying a 23andMe genetic test. You’re genetic data may be shared by big Pharma.
Here’s what you should know.

Read on…

DNA Privacy Concerns

Here is a wonderful article to take the guilt out of eating dark chocolate. It needs to be at least “70% cacao” according to the most recent studies this year carried out by Loma Linda University.

The benefits are impressive which include reducing stress levels, inflammation, improving mood, memory and immunity. It may even help neuroplasticity of the brain which can help the brain adapt to changing demands which results in learning and acquiring new skills.

So enjoy a nice piece of dark chocolate after dinner…it’s good for you!

Science says one of your tastiest habits might be good for you

What I sometimes see is elevated levels of DHEA and other hormones in women that are not on supplements. Where are these hormones coming from?  I often check thyroid and adrenal hormones for symptoms such as fatigue, weight gain, hair loss, and mood changes. Estrogen and Progesterone levels are also evaluated for insomnia, hot flushes and peri-menopausal symptoms.

There are several body products that have hidden endocrine disruptors which raise hormone levels in women (and men). Endocrine disrupting chemicals are substances in our environment (heated plastics, pesticides, etc), water, food, and personal care products that interfere withe the production, transport, metabolism, binding and elimination of hormones. These chemicals ultimately effect the balance of the body and can cause symptoms as I mentioned above, in addition to obesity, diabetes and certain cancers.

So when I see elevated hormones I recommend a detox program which consists of  healthy exercise, lots of water (half your body weight in ounces), and healthy fats (omega-3 fatty acids and flax seeds). I encourage dark leafy vegetables and colorful fruits with lean proteins. Avoid sugars, alcohol and processed foods. I will add a liver detox supplement to help clear liver pathways to flush out toxins. Healthy bowel movements are also important for detoxing.

Then we start investigating….

What body products, cosmetics, shampoos and other topical products are you using? Here is a common list of what to avoid that could be raising your hormone levels and risk for hormone imbalance and other chronic health illnesses.

1. Parabens (propyl-, Isopropyl-, Butyl-, and Isobutyl)- are used as preservatives in many products. Parabens were detected in breast tumors in a published study in the Journal of Applied Toxicology in 2004. The estrogenic activity in the body while using these products are very low but it is worth making sure you are not using several products on a daily basis that may accumulate.
2. Placental Extracts- contain estrogen, estrone and progesterone as contaminants. They are found in shampoos, conditioners, moisturizers, astringents and skin creams. Some common ingredients that may be derived from human or animal placenta’s are hyaluronic acid, collagen-elastin complex and glucosaminoglycans.                                                                                                  I recommend getting hyaluronic acid naturally in foods since it’s a carbohydrate found naturally in our bodies tissues and helps support skin cell renewal, skin elasticity and collagen production (which is why many synthetic anti-aging creams have this in it). Foods highest in hyaluronic acid are root vegetables (sweet potatoes, turnips, parsnips and carrots), bone broth, organ meats (pork, poultry, beef, lamb and especially liver), and soy products.
3. Benzophenones- are UVA sun filters. These chemicals are mainly in sunscreens. The majority of studies have tested positive as a weak environmental estrogen. These chemicals accumulate in fatty tissue and are also linked to allergies.
4. Fragrance- has hormone disrupting effects. It is also connected to headaches, dizziness, asthma and allergies.
5. Petrochemicals- such as mineral oil is used as an emollient and lubricant because it’s cheap and easily accessible. According to the U.S. Department of Health and Human Services, it has been classified as a carcinogen and can be contaminated with xenoestrogenic polycyclic aromatic hydrocarbons (PAH). These chemicals are known to activate estrogen receptors and may cause proliferation of certain breast cancer cells.
6. Lead- is a known carcinogen and hormone disruptor. It is found in certain eyeliners, hair dye and lipsticks.                                                                                                                                                                                                                                                                                                                                                                                       See your practitioner and get tested to see if you have hidden hormone imbalances that may be causing symptoms or leading to chronic illness.

Robert Silverman, DC has written a compelling article describing how It’s an interesting concept considering how many people have delayed recovery of this common, but not well-understood condition. So how does this occur?

First, we need to know that traumatic brain injury (TBI) is something that does not just occur with football players. It can happen in a car accident, slipping and falling, or impact with any contact sport. Immediately following a head injury or several weeks after the event, a patient may experience a variety of symptoms. These can include headaches, vomiting, lethargy, and irritability. TBI can also have long-term effects on the musculoskeletal system, gastrointestinal tract and the immune system. These problems sometimes takes months to emerge from the initial accident.

After a head injury, the brain becomes inflammed. We are not sure why, but this leads to inflammation in the gut. It also happens very quickly…within hours. This gut inflammation increases intestinal permeability which allows large, immunogenic (substances that are able to produce an immune response) dietary proteins and bacterial toxins into the bloodstream. Inflammation in the bloodstream follows which keeps the blood-brain barrier (BBB) open and fuels the inflammation in the brain. The intestinal mucosa is the most nutrient-dependent, toxin vulnerable organ in the body. So when the intestinal villi are destroyed due to inflammation after a TBI, then it compromises the patients ability to absorb important nutrients for healing and repair. Also, the compromised BBB allows entry of more circulating substances that provoke the immune system, fueling the neurological inflammation. It’s a double whammy!

Knowing what structures are breaking down in the gut is important. Blood tests for certain bacterial toxins such as Lipopolysaccharides (LPS) and distending toxin-B (CdtB) are recommended to determine the state of a patients gut health. The sooner you test the better, because delays identifying this cycle results in greater neurological tissue damage and reduced quality of life.

Reference: Silverman, R. “Gut Dysfunction Frequently Follows Traumatic Brain Injury”. Holistic Primary Care, Spring 2018, p. 8

In 2011, investigators discovered that a bacteria known as Fusobacteria, is often found in colon cancer tissue. Even though the bacteria may be an innocent bystander, it might also be a causative agent for colon cancer, much the same way as Helicobacteria pylori can be for gastric carcinoma.

In a new multicenter study, researchers pooled over 500 cases of colorectal cancer and confirmed that fusobacterial DNA was found in nearly 50% of primary tumors. They also found that this bacteria and it’s proteins were primarily in malignant cells rather than in non-malignant cells. This bacteria was cultured from primary and metastatic tumors.

Also, human colon cancer cells that were positive for fusobacterial DNA often grew into tumors when implanted in mice. When cells from those tumors were transplanted into other mice, they retained their bacterial DNA and grew into new tumors. When mice with tumors containing fusobacteria DNA were treated with metronidazole, an antibiotic to which fusobacteria are sensitive, tumor growth decreased. This did not occur with other antibiotics to which the bacteria was not sensitive.

This study suggests that such tumors might be prevented and treated by antimicrobial agents. More studies are needed, but this and more studies may lead to breakthroughs in cancer treatments.

Bullman S et al. Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science 2017 Dec. 15; 358:1443.

When we feel miserable with a sinus infection, we just want a magic pill to make the symptoms go away. Some people expect to go to their doctor and get an antibiotic for treatment. This can be a bad idea if it’s not the cause of the infection. We live in a time where antibiotic resistance is a big problem. Handing out antibiotics for treating colds that are due to viruses, is the main reason for this resistance problem. So here are some things to know…

The correct term is actually, “rhinosinusitis.” This is when the mucous lining in the paranasal sinuses and nasal cavity become inflammed. It effects 1 in 7 adults each year in the U.S. It causes swelling and blockage of the normal openings that drain mucous. It also decreases the function of cilia (small hair-like structures) which are responsible for sweeping out mucous and debri from the nasal cavity.

Most (>80%) infections are due to viruses, which originate from the common “cold”. We catch these colds from direct contact by touching a surface with the virus on it and then touching our face, wiping our nose or mouth. The other way it is spread is through airborne droplets that occur when someone coughs.

In the first 3-4 days of illness,  you can’t tell a viral or bacterial infection apart. Symptoms are similar which includes nasal congestion, runny nose, loss of smell or taste, post nasal drip, sore throat, tooth and facial pain/pressure, fatigue, headache, bad breath and fever. Thick green mucous does not mean it is a bacterial infection needing antibiotics. This can be viral or it can indicate that the infection is coming to the end of its cycle and almost cleared.

During the first 7-10 days, it is best to do nasal washes with saline which you can make on your own, using 1 cup of warm filtered water and adding 1/4 tsp of sea salt and 1/8 tsp of baking soda. You can also use this solution for gargling if you have a sore throat. Decongestants are also helpful with nasal swelling and post nasal drip. You can try a homeopathic remedy or use over-the-counter Sudafed. Drink lots of water, get rest and fresh air. Exercise is fine as long as you are not running a fever. Try to avoid sugar, alcohol and coffee which can compromise the immune system.

So when to think about antibiotics? If your symptoms worsen over 10 days or you improve after the first few days and then your symptoms come back much worse. Also, predominant sinus pain on one side and discharge that looks like pus are times when you should see your practitioner.

Always wash your hands and cover your mouth with your arm or a tissue, (rather than your hands) when sneezing or coughing. Try to stay away from sick people if you can. There are some people that need to be referred to a specialist if symptoms continue to worsen after maximum treatment.

Aring, A et al. Current Concepts in Adult Acute Rhinosinusitis. American Family Physician. July 15, 2016 Vol. 94. Number 2