Polycystic Ovarian Syndrome (PCOS) affects 5-18% of women and is the most common endocrine disorder of reproductive age around the world. It is a set of symptoms related to an imbalance of hormones and has 4 different phenotypes. The cause is unknown but genetics and environmental factors play a role. Symptoms include menstrual irregularities, acne, ovarian cysts, excess hair growth and metabolic dysfunction leading to obesity. These symptoms are an effect of high insulin and high androgen levels. These high levels of insulin can lead to diabetes, infertility and heart disease. Now there’s a new kid on the block which are the peptides known as GLP-1 Agonists (Semaglutide, Tirzepatide). Polycystic Ovarian Syndrome and GLP-1 Agonist treatments have been gaining alot of popularity lately.
Traditional treatments for PCOS include birth control pills, Metformin to manage insulin and prevent diabetes, statins to control high cholesterol, hormones to increase fertility, and procedures to remove excess hair. Thats alot of medications to treat a constellation of symptoms!
One 14-week study showed that GLP 1 reduced insulin and testosterone up to 2 years after stopping the drug.
A recent meta-analysis on the efficacy and safety of a GLP-1 vs Metformin found that compared with Metformin, GLP-1 agonists were more effective in reducing weight and improving insulin sensitivity. One 14-week study showed that GLP 1 reduced insulin and testosterone up to 2 years after stopping the drug. Cycles became regular! By helping insulin regulation, GLP-1 helps acne, excess hair growth, weight gain and irregular cycles. These changes also reduce the risks for future diabetes and heart disease.
There are many natural alternative treatments that I’ll discuss in future posts…